Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Antidepressant imipramine induces human astrocytes to differentiate into cells with neuronal phenotype.

The international journal of neuropsychopharmacology - 1 Jun 2010

Cabras Stefano, Saba Francesca, Reali Camilla, Scorciapino Maria Laura, Sirigu Annarita, Talani Giuseppe, Biggio Giovanni, Sogos Valeria

Abstract excerpt

Several recent studies have expanded our conception of the role of astrocytes in neurogenesis, proposing that these cells may contribute to this phenomenon not only as a source of trophic substances, but also as stem cells themselves. We recently observed in vitro that human mature astrocytes can be induced to differentiate into cells with a neuronal phenotype. Antidepressant drugs have been shown to increase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antidepressive Agents, Tricyclic
Share to Astrocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Differentiation

Share to Glial Fibrillary Acidic Protein

Share to Neurogenesis

Share to Neurons

Share to Stem Cells

Source

Identifiers

PMID: 20356437
DOI: 10.1017/S1461145710000210

Genes

GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Antidepressant imipramine induces human astrocytes to differentiate into cells with neuronal phenotype.PMID 20356437Read ↗

An update on human astrocytes and their role in development and diseaseSemantic proximity Read ↗

Differentiation of human adult CD34+ stem cells into cells with a neural phenotype: role of astrocytes.Semantic proximity Read ↗

The effects of different phenotype astrocytes on neural stem cells differentiation in co-culture.Semantic proximity Read ↗

Differential and paradoxical roles of new-generation antidepressants in primary astrocytic inflammationSemantic proximity Read ↗

Early acquisition of typical metabolic features upon differentiation of mouse neural stem cells into astrocytes.Semantic proximity Read ↗

Transient differentiation of adult human bone marrow cells into neuron-like cells in culture: development of morphological and biochemical traits is mediated by different molecular mechanisms.Semantic proximity Read ↗

Electroconvulsive seizure treatment increases cell proliferation in rat frontal cortex.Semantic proximity Read ↗

Plasticity of astrocytes.Semantic proximity Read ↗

Differentiation into neurons of rat bone marrow-derived mesenchymal stem cellsSemantic proximity Read ↗

Apolipoprotein E expression pattern in human induced pluripotent stem cells during in vitro neural inductionSemantic proximity Read ↗

N-3 polyunsaturated fatty acids promote astrocyte differentiation and neurotrophin production independent of cAMP in patient-derived neural stem cellsSemantic proximity Read ↗

Long-lasting coexpression of nestin and glial fibrillary acidic protein in primary cultures of astroglial cells with a major participation of nestin(+)/GFAP(-) cells in cell proliferation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.