Article
Genetic risks for children of women with myotonic dystrophy.
American journal of human genetics - 1 Jun 1991
Koch M C, Grimm T, Harley H G, Harper P S
Abstract excerpt
In genetic counseling, the recommended risk estimate that any heterozygous woman with myotonic dystrophy (DM) will have a congenitally affected child is 3%-9%. However, after already having had such an offspring, a DM mother's risk increases to 20%-37%. The risks of 10% and 41%, respectively, calculated in this study are similar to the estimates in the literature. However, our data on clinical status of the...
Topics
- Adolescent
- Adult
- Child
- Child, Preschool
- Chromosomes, Human, Pair 19
- Female
- Heterozygote
- Humans
- Infant
- Infant, Newborn
- Mutation
- Myotonic Dystrophy