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Leishmania donovani: genetic diversity of isolates from Sudan characterized by PCR-based RAPD.

Experimental parasitology - 1 Aug 2010

Hamad S H, Khalil E A G, Musa A M, Ibrahim M E, Younis B M, Elfaki M E E, El-Hassan A M

Abstract excerpt

Drug unresponsiveness in patients with visceral leishmaniasis (VL) is a problem in many endemic areas. This study aimed to determine genetic diversity of Leishmania donovani isolates from a VL endemic area in Sudan as a possible explanation for drug unresponsiveness in some patients. Thirty clinically stibogluconate (SSG)-sensitive isolates were made SSG-unresponsive in vitro by gradually increasing SSG...

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PMID: 20346944
DOI: 10.1016/j.exppara.2010.03.008

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