Article
Analysis of ER stress in developing rice endosperm accumulating beta-amyloid peptide.
Plant biotechnology journal - 1 Aug 2010
Oono Youko, Wakasa Yuhya, Hirose Sakiko, Yang Lijun, Sakuta Chiyoko, Takaiwa Fumio
Abstract excerpt
The common neurodegenerative disorder known as Alzheimer's disease is characterized by cerebral neuritic plaques of amyloid beta (Abeta) peptide. Plaque formation is related to the highly aggregative property of this peptide, because it polymerizes to form insoluble plaques or fibrils causing neurotoxicity. Here, we expressed Abeta peptide as a new causing agent to endoplasmic reticulum (ER) stress to study ER...
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