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Functional delivery of viral miRNAs via exosomes

18 Mar 2010

Abstract excerpt

Noncoding regulatory microRNAs (miRNAs) of cellular and viral origin control gene expression by repressing the translation of mRNAs into protein. Interestingly, miRNAs are secreted actively through small vesicles called "exosomes" that protect them from degradation by RNases, suggesting that these miRNAs may function outside the cell in which they were produced. Here we demonstrate that miRNAs secreted by...

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PMID: 20304794
DOI: 10.1073/pnas.0914843107

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