Gene manipulation with stereotaxic viral infection for psychiatric research: spatiotemporal components for schizophrenia.

Abstract excerpt

Schizophrenia (SZ) is a highly polygenic disease with strong genetic predisposition. Although genetic susceptibility factors for SZ are likely to have an influence in some brain regions and related neural circuits during neurodevelopment, direct proof for spatiotemporal causality in the development of SZ, and the alteration of what gene function at what brain region during what developmental stage, remains to be...

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