Article
miR-24 regulates apoptosis by targeting the open reading frame (ORF) region of FAF1 in cancer cells.
PloS one - 25 Feb 2010
Qin Wenming, Shi Yi, Zhao Botao, Yao Chengguo, Jin Li, Ma Jiexian, Jin Youxin
Abstract excerpt
BACKGROUND: microRNAs (miRNAs) are small noncoding RNAs that regulate cognate mRNAs at the post-transcriptional stage. Several studies have shown that miRNAs modulate gene expression in mammalian cells by base pairing to complementary sites in the 3'-untranslated region (3'-UTR) of the target mRNAs. METHODOLOGY/PRINCIPAL FINDINGS: In the present study, miR-24 was found to target fas associated factor 1(FAF1) by...
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