Article
The mutations of Th1 cell-specific T-box transcription factor may be associated with a predominant Th2 phenotype in gastric cancers.
International journal of immunogenetics - 1 Apr 2010
Yang P, Qiu G, Wang S, Su Z, Chen J, Wang S, Kong F, Lu L, Ezaki T, Xu H
Abstract excerpt
Gastric cancer is a serious public health cancer and causes nearly 1 million deaths a year worldwide. Th1 cells play critical roles in orchestrating the adaptive immune responses against gastric cancer. T-bet, a member of the T-box family of transcription factors, is the Th1 master regulator and up-regulated during Th1 differentiation. Polymorphisms have also been shown to exist in T-bet. Some reports indicated...
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