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Phylogenetic Analysis of the MS4A and TMEM176 Gene Families

22 Feb 2010

Abstract excerpt

BACKGROUND: The MS4A gene family in humans includes CD20 (MS4A1), FcRbeta (MS4A2), Htm4 (MS4A3), and at least 13 other syntenic genes encoding membrane proteins, most having characteristic tetraspanning topology. Expression of MS4A genes is variable in tissues throughout the body; however, several are limited to cells in the hematopoietic system where they have known roles in immune cell functions. Genes in the...

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PMID: 20186339
DOI: 10.1371/journal.pone.0009369

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