Accurate Outcome Prediction in Neuroblastoma across Independent Data Sets Using a Multigene Signature

Abstract excerpt

PURPOSE: Reliable prognostic stratification remains a challenge for cancer patients, especially for diseases with variable clinical course such as neuroblastoma. Although numerous studies have shown that outcome might be predicted using gene expression signatures, independent cross-platform validation is often lacking. EXPERIMENTAL DESIGN: Using eight independent studies comprising 933 neuroblastoma patients, a...

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