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Reassortment between avian H5N1 and human H3N2 influenza viruses creates hybrid viruses with substantial virulence

22 Feb 2010

Abstract excerpt

The spread of avian H5N1 influenza viruses around the globe has become a worldwide public health concern. To evaluate the pathogenic potential of reassortant viruses between currently cocirculating avian H5N1 and human H3N2 influenza viruses, we generated all the 254 combinations of reassortant viruses between A/chicken/South Kalimantan/UT6028/06 (SK06, H5N1) and A/Tokyo/Ut-Sk-1/07 (Tok07, H3N2) influenza viruses...

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PMID: 20176961
DOI: 10.1073/pnas.0912807107

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