Article
The cag PAI is intact and functional but HP0521 varies significantly in Helicobacter pylori isolates from Malaysia and Singapore.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology - 1 Apr 2010
Schmidt H-M A, Andres S, Nilsson C, Kovach Z, Kaakoush N O, Engstrand L, Goh K-L, Fock K M, Forman D, Mitchell H
Abstract excerpt
Helicobacter pylori-related disease is at least partially attributable to the genotype of the infecting strain, particularly the presence of specific virulence factors. We investigated the prevalence of a novel combination of H. pylori virulence factors, including the cag pathogenicity island (PAI), and their association with severe disease in isolates from the three major ethnicities in Malaysia and Singapore,...
Topics
- Adult
- Antigens, Bacterial
- Bacterial Proteins
- Cells, Cultured
- DNA, Bacterial
- Epithelial Cells
- Genetic Variation
- Genomic Islands
- Helicobacter Infections