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Toll‐like receptor 9 expression in breast and ovarian cancer is associated with poorly differentiated tumors

12 Jan 2010

Abstract excerpt

Toll-like receptor 9 (TLR9) activates the innate immune response when exposed to non-methylated CpG-DNA. TLR9 was recently shown to be expressed by cancer cells which have been previously characterized by global hypomethylation. We set out to examine the expression and molecular activity of TLR9 in breast and ovarian cancer cells. Firstly, we confirmed higher levels of hypomethylated DNA in the serum of patients...

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PMID: 20156214
DOI: 10.1111/j.1349-7006.2010.01491.x

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