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Article

The structure of the harmonin/sans complex reveals an unexpected interaction mode of the two Usher syndrome proteins.

Proceedings of the National Academy of Sciences of the United States of America - 2 Mar 2010

Yan Jing, Pan Lifeng, Chen Xiuye, Wu Lin, Zhang Mingjie

Abstract excerpt

The hereditary hearing-vision loss disease, Usher syndrome I (USH1), is caused by defects in several proteins that can interact with each other in vitro. Defects in USH1 proteins are thought to be responsible for the developmental and functional impairments of sensory cells in the retina and inner ear. Harmonin/USH1C and Sans/USH1G are two of the USH1 proteins that interact with each other. Harmonin also binds to...

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Identifiers

PMID: 20142502
DOI: 10.1073/pnas.0911385107
PMCID: PMC2840103

Genes

CDH23
PCDH15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The structure of the harmonin/sans complex reveals an unexpected interaction mode of the two Usher syndrome proteins.PMID 20142502Read ↗

Interactions in the network of Usher syndrome type 1 proteins.Semantic proximity Read ↗

Characterization of the ternary Usher syndrome SANS/ush2a/whirlin protein complex.Semantic proximity Read ↗

Molecular basis of human Usher syndrome: deciphering the meshes of the Usher protein network provides insights into the pathomechanisms of the Usher disease.Semantic proximity Read ↗

Molecular analysis of the supramolecular usher protein complex in the retina. Harmonin as the key protein of the Usher syndrome.Semantic proximity Read ↗

Expression and subcellular localization of <i>USH1C</i> /harmonin in the human retina provide insights into pathomechanisms and therapySemantic proximity Read ↗

SANS (USH1G) regulates pre-mRNA splicing by mediating the intra-nuclear transfer of tri-snRNP complexesSemantic proximity Read ↗

Deafness-Associated ADGRV1 Mutation Impairs USH2A Stability through Improper Phosphorylation of WHRN and WDSUB1 Recruitment.Semantic proximity Read ↗

Nuclear-Cytoplasmic Shuttling of the Usher Syndrome 1G Protein SANS Differs from Its Paralog ANKS4B.Semantic proximity Read ↗

Pathogenic Variants in USH1G/SANS Alter the Protein Interaction With the Pre-RNA Processing Factors PRPF6 and PRPF31 of the SpliceosomeSemantic proximity Read ↗

Lack of PDZD7 long isoform disrupts ankle-link complex and causes hearing loss in mice.Semantic proximity Read ↗

Structure of Myo7b/USH1C complex suggests a general PDZ domain binding mode by MyTH4-FERM myosinsSemantic proximity Read ↗

A remarkable case of conserved domain swapping in the COMMD family of proteinsSemantic proximity Read ↗

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