Article
Intracellular localization of metaiodobenzyl guanidine in human neuroblastoma cells by electron spectroscopic imaging
1 Apr 1991
Abstract excerpt
The targeted radiotherapy of neuroblastoma with 131l-labelled metaiodobenzyl guanidine (mIBG) is now the subject of several clinical studies. The precise intracellular localization of mIBG, necessary for nuclear microdosimetry, has not previously been described. We report the use of electron-energy-loss spectroscopy and electron spectroscopic imaging to establish the intracellular distribution of mIBG in cells...