Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Application of gene network analysis techniques identifies AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic valve.

PloS one - 21 Jan 2010

Wooten Eric C, Iyer Lakshmanan K, Montefusco Maria Claudia, Hedgepeth Alyson Kelley, Payne Douglas D, Kapur Navin K, Housman David E, Mendelsohn Michael E, Huggins Gordon S

Abstract excerpt

Bicuspid Aortic Valve (BAV) is a highly heritable congenital heart defect. The low frequency of BAV (1% of general population) limits our ability to perform genome-wide association studies. We present the application of four a priori SNP selection techniques, reducing the multiple-testing penalty...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD
Share to Aortic Valve
Share to Axin Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endoglin

Share to Gene Regulatory Networks

Share to Heart Defects, Congenital

Share to Protein Disulfide-Isomerases

Share to Receptors, Cell Surface

Source

Open in PubMed Open full text

Identifiers

PMID: 20098615
DOI: 10.1371/journal.pone.0008830
PMCID: PMC2809109

Genes

AXIN1
PDIA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20098615-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Application of gene network analysis techniques identifies AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic valve.PMID 20098615Read ↗

Genome and Transcriptome-Wide Analyses Identify Multiple Candidate Genes and a Significant Polygenic Contribution in Bicuspid Aortic Valve.Semantic proximity Read ↗

Whole exome sequencing for familial bicuspid aortic valve identifies putative variants.Semantic proximity Read ↗

Rare Genomic Copy Number Variants Implicate New Candidate Genes for Bicuspid Aortic ValveSemantic proximity Read ↗

Rare genomic copy number variants implicate new candidate genes for bicuspid aortic valve.Semantic proximity Read ↗

Use of a targeted, combinatorial next-generation sequencing approach for the study of bicuspid aortic valve.Semantic proximity Read ↗

Identification of Gender-Specific Genetic Variants in Patients With Bicuspid Aortic Valve.Semantic proximity Read ↗

Artificial Intelligence and Cardiovascular GeneticsSemantic proximity Read ↗

Genetic abnormalities in bicuspid aortic valve root phenotype: preliminary results.Semantic proximity Read ↗

Artificial Intelligence Models Reveal Sex-Specific Gene Expression in Aortic Valve CalcificationSemantic proximity Read ↗

Evidence in favor of linkage to human chromosomal regions 18q, 5q and 13q for bicuspid aortic valve and associated cardiovascular malformations.Semantic proximity Read ↗

Novel Association of the NOTCH Pathway Regulator MIB1 Gene With the Development of Bicuspid Aortic ValveSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.