Article
Bone mineral density and vitamin D receptor polymorphism in beta-thalassemia major.
Pakistan journal of pharmaceutical sciences - 1 Jan 2010
El-Edel Rawhia H, Ghonaim Mabrouk M, Abo-Salem Osama M, El-Nemr Fathia M
Abstract excerpt
Osteoporosis is the most prevalent bone complication in beta-thalassemic patients despite regular transfusions and iron chelation therapy. Although its etiology is multi-factorial, genetic factors play an important role in pathogenesis. These factors have not yet been clearly defined, however, osteoporosis may be related to vitamin D receptor gene BsmI polymorphism. In this study, BsmI vitamin D receptor gene...
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