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Article

Analysis of recombination and natural selection in human enterovirus 71.

Virology - 15 Mar 2010

Chen Xiaoming, Zhang Qian, Li Jinghua, Cao Wei, Zhang Jin-Xia, Zhang Lei, Zhang Weilu, Shao Zhong-Jun, Yan Yongping

Abstract excerpt

The development of effective vaccines and antiviral prophylaxis against human enterovirus 71 (EV71) has been hampered by the extensive antigenic diversity of the virus. To gain new insights into the evolutionary processes that create this genetic diversity, the TreeOrder Scan Method and RDP program were employed to detect recombination events in the genome, and then parsimony-based and maximum-likelihood-based...

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Identifiers

PMID: 20060995
DOI: 10.1016/j.virol.2009.12.007

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