Opening up the "Black Box": metabolic phenotyping and metabolome-wide association studies in epidemiology.

doi:10.1016/j.jclinepi.2009.10.001

Article

Opening up the "Black Box": metabolic phenotyping and metabolome-wide association studies in epidemiology.

Journal of clinical epidemiology - 1 Sept 2010

Bictash Magda, Ebbels Timothy M, Chan Queenie, Loo Ruey Leng, Yap Ivan K S, Brown Ian J, de Iorio Maria, Daviglus Martha L, Holmes Elaine, Stamler Jeremiah, Nicholson Jeremy K, Elliott Paul

Abstract excerpt

BACKGROUND: Metabolic phenotyping of humans allows information to be captured on the interactions between dietary, xenobiotic, other lifestyle and environmental exposures, and genetic variation, which together influence the balance between health and disease risks at both individual and population levels. OBJECTIVES: We describe here the main procedures in large-scale metabolic phenotyping and their application...

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Opening up the "Black Box": metabolic phenotyping and metabolome-wide association studies in epidemiology.

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