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Article

Activation of retinal guanylyl cyclase RetGC1 by GCAP1: stoichiometry of binding and effect of new LCA-related mutations.

Biochemistry - 2 Feb 2010

Peshenko Igor V, Olshevskaya Elena V, Yao Suxia, Ezzeldin Hany H, Pittler Steven J, Dizhoor Alexander M

Abstract excerpt

Retinal membrane guanylyl cyclase (RetGC) and Ca(2+)/Mg(2+) sensor proteins (GCAPs) control the recovery of the photoresponse in vertebrate photoreceptors, through their molecular interactions that remain rather poorly understood and controversial. Here we have determined the main RetGC isozyme (...

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Identifiers

PMID: 20050595
DOI: 10.1021/bi901495y
PMCID: PMC2827208

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20050595-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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