Article
Screening for EGFR mutations in lung cancer.
Discovery medicine - 1 Dec 2009
Molina-Vila Miguel A, Bertran-Alamillo Jordi, Mayo Clara, Rosell Rafael
Abstract excerpt
Certain mutations in the epidermal growth factor receptor (EGFR) gene confer hypersensitivity to the tyrosine kinase inhibitors gefitinib and erlotinib in patients with advanced non-small cell lung cancer. Large-scale screening for EGFR mutations in such patients is feasible for predicting response to TKIs and thus guiding treatment.
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