Article
Hypophosphatemia, hyperphosphaturia, and bisphosphonate treatment are associated with survival beyond infancy in generalized arterial calcification of infancy.
Circulation. Cardiovascular genetics - 1 Dec 2008
Rutsch Frank, Böyer Petra, Nitschke Yvonne, Ruf Nico, Lorenz-Depierieux Bettina, Wittkampf Tanja, Weissen-Plenz Gabriele, Fischer Rudolf-Josef, Mughal Zulf, Gregory John W, Davies Justin H, Loirat Chantal, Strom Tim M, Schnabel Dirk, Nürnberg Peter, Terkeltaub Robert
Abstract excerpt
BACKGROUND: Generalized arterial calcification of infancy has been reported to be frequently lethal, and the efficiency of any therapy, including bisphosphonates, is unknown. A phosphate-poor diet markedly increases survival of NPP1 null mice, a model of generalized arterial calcification of infancy. METHODS AND RESULTS: We performed a multicenter genetic study and retrospective observational analysis of 55...
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