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Mechanisms of anti-D action in the prevention of hemolytic disease of the fetus and newborn

1 Jan 2009

Abstract excerpt

Anti-D is routinely and effectively used to prevent hemolytic disease of the fetus and newborn (HDFN) caused by the antibody response to the D antigen on fetal RBCs. Anti-D is a polyclonal IgG product purified from the plasma of D-alloimmunized individuals. The mechanism of anti-D has not been fully elucidated. Antigenic epitopes are not fully masked by anti-D and are available for immune system recognition....

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Identifiers

PMID: 20008198
DOI: 10.1182/asheducation-2009.1.185

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