Article
APOE-epsilon3 and APOE-219G haplotypes increase the risk for schizophrenia in sibling pairs.
The Journal of neuropsychiatry and clinical neurosciences - 1 Jan 2009
Tovilla-Zarate Carlos, Medellin Beatriz Camarena, Fresan Ana, Apiquian Rogelio, Dassori Albana, Rolando Medina, Escamilla Michael, Nicolini Humberto
Abstract excerpt
To investigate the role of the apolipoprotein E (APOE) gene in schizophrenia, the authors analyzed 60 families with this mental disorder. An association in the presence of linkage test (APL) and haplotypes analysis were undertaken using the APL v1.1 software. A global allelic transmitted was significant for APOE-epsilon3 (chi(2)=6.24, p=0.01); this allele is mainly carried by female patients (chi(2)=8.33,...
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