Cytological and biochemical analyses of the maternal-effect mutant embryos with abnormal cleavage furrow formation in Xenopus laevis.

Abstract excerpt

We describe an embryonic lethal mutation in Xenopus laevis that provokes regression of cleavage furrow formation. The mutant females (designated as af) were obtained by the back-cross of a female with one of her sons. All the fertilized eggs laid by the mutant females, regardless of the wild-type male used in the mating, failed to cleave although each furrow ran at a proper position superficially. Light and...

Topics

• Animals
• Cell Division
• Cleavage Stage, Ovum
• Electrophoresis, Gel, Two-Dimensional
• Genes, Lethal
• Genes, Recessive
• Isoelectric Point
• Molecular Weight
• Mutation
• Proteins
• Xenopus laevis