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Article

Partial loss of heterozygosity events at the mutated gene in tumors from MLH1/MSH2 large genomic rearrangement carriers.

BMC cancer - 20 Nov 2009

Zavodna Katarina, Krivulcik Tomas, Bujalkova Maria Gerykova, Slamka Tomas, Martinicky David, Ilencikova Denisa, Bartosova Zdena

Abstract excerpt

BACKGROUND: Depending on the population studied, large genomic rearrangements (LGRs) of the mismatch repair (MMR) genes constitute various proportions of the germline mutations that predispose to hereditary non-polyposis colorectal cancer (HNPCC). It has been reported that loss of heterozygosity...

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Topics

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Share to Adaptor Proteins, Signal Transducing
Share to Base Sequence
Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Rearrangement

Share to Loss of Heterozygosity

Share to MutL Protein Homolog 1

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Source

Open in PubMed Open full text

Identifiers

PMID: 19930554
DOI: 10.1186/1471-2407-9-405
PMCID: PMC2788582

Genes

MSH2
MLH1
MSH6
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19930554-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Partial loss of heterozygosity events at the mutated gene in tumors from MLH1/MSH2 large genomic rearrangement carriers.PMID 19930554Read ↗

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