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Article

Translating metabolic exchange with imaging mass spectrometry.

Nature chemical biology - 1 Dec 2009

Yang Yu-Liang, Xu Yuquan, Straight Paul, Dorrestein Pieter C

Abstract excerpt

Metabolic exchange between an organism and the environment, including interactions with neighboring organisms, is important for processes of organismal development. Here we develop and use thin-layer agar natural product MALDI-TOF imaging mass spectrometry of intact bacterial colonies grown on top of the MALDI target plate to study an interaction between two species of bacteria and provide direct evidence that...

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PMID: 19915536
DOI: 10.1038/nchembio.252
PMCID: PMC2778862

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