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Article

NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with procarbazine, lomustine, and vincristine or temozolomide.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Dec 2009

Wick Wolfgang, Hartmann Christian, Engel Corinna, Stoffels Mandy, Felsberg Jörg, Stockhammer Florian, Sabel Michael C, Koeppen Susanne, Ketter Ralf, Meyermann Richard, Rapp Marion, Meisner Christof, Kortmann Rolf D, Pietsch Torsten, Wiestler Otmar D, Ernemann Ulrike, Bamberg Michael, Reifenberger Guido, von Deimling Andreas, Weller Michael

Abstract excerpt

PURPOSE: The standard of care for anaplastic gliomas is surgery followed by radiotherapy. The NOA-04 phase III trial compared efficacy and safety of radiotherapy followed by chemotherapy at progression with the reverse sequence in patients with newly diagnosed anaplastic gliomas. PATIENTS AND METHODS: Patients (N = 318) were randomly assigned 2:1:1 (A:B1:B2) to receive conventional radiotherapy (arm A);...

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Antineoplastic Agents, Alkylating
Chemotherapy, Adjuvant
Dacarbazine
DNA Modification Methylases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Drug Administration Schedule

Radiotherapy, Adjuvant

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Identifiers

PMID: 19901110
DOI: 10.1200/JCO.2009.23.6497

Genes

MGMT
IDH1

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