Association of INT2/HST1 coamplification in primary breast cancer with hormone-dependent phenotype and poor prognosis.

doi:10.1038/bjc.1991.28

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Association of INT2/HST1 coamplification in primary breast cancer with hormone-dependent phenotype and poor prognosis.

British journal of cancer - 1 Jan 1991

Borg A, Sigurdsson H, Clark G M, Fernö M, Fuqua S A, Olsson H, Killander D, McGurie W L

Abstract excerpt

The human proto-oncogene INT2 (homologous to the mouse INT2 gene, implicated in proviral induced mammary carcinoma) has been mapped to chromosome 11q13 and found to share band localisation with, among others, the HST1 proto-oncogene. Both genes are members of the fibroblast growth factor family. In the present study, coamplification (2-15 copies) of the INT2/HST1 genes was found in 27 (9%) of 311 invasive human...

Topics

Adult
Aged
Aged, 80 and over
Breast Neoplasms
Estrogens
Female
Gene Amplification
Humans
Lymphatic Metastasis
Middle Aged
Multivariate Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasms, Hormone-Dependent

Phenotype

Prognosis

Proto-Oncogene Mas

Proto-Oncogenes

Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 1989653
DOI: 10.1038/bjc.1991.28
PMCID: PMC1971653

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1989653-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Association of INT2/HST1 coamplification in primary breast cancer with hormone-dependent phenotype and poor prognosis.PMID 1989653Read ↗

EMS1 amplification can occur independently of CCND1 or INT-2 amplification at 11q13 and may identify different phenotypes in primary breast cancer.Semantic proximity Read ↗

c‐myc amplification is an independent prognostic factor in postmenopausal breast cancerSemantic proximity Read ↗

Cox-2 and Her2/neu co-expression in invasive bladder cancerSemantic proximity Read ↗

Analysis of gene amplification and overexpression in human esophageal‐carcinoma cell linesSemantic proximity Read ↗

Prognostic Relevance of Gene Amplifications and Coamplifications in Breast CancerSemantic proximity Read ↗

ERBB2-amplified lobular breast carcinoma exhibits concomitant CDK12 co-amplification associated with poor prognostic features.Semantic proximity Read ↗

Natural History and Characteristics of ERBB2-mutated Hormone Receptor-positive Metastatic Breast Cancer: A Multi-institutional Retrospective Case-control Study from AACR Project GENIE.Semantic proximity Read ↗

Activation of multiple cancer-associated genes at the <i>ERBB2</i> amplicon in breast cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.