Article
Oxidative stress of Burkholderia cenocepacia induces insertion sequence-mediated genomic rearrangements that interfere with macrorestriction-based genotyping.
Journal of clinical microbiology - 1 Jan 2010
Drevinek Pavel, Baldwin Adam, Lindenburg Laurens, Joshi Lovleen Tina, Marchbank Angela, Vosahlikova Sarka, Dowson Christopher G, Mahenthiralingam Eshwar
Abstract excerpt
Burkholderia cenocepacia can cause serious infections and epidemics in patients with cystic fibrosis (CF). A CF population in the Czech Republic experienced an epidemic outbreak caused by a B. cenocepacia ST-32 strain. The clonality of the isolates was evident by multilocus sequence typing; however, fingerprinting profiles obtained by pulsed-field gel electrophoresis (PFGE) showed substantial band variability. We...
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