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Translational Regulation by the 3′ Untranslated Region of the Dengue Type 2 Virus Genome

27 Oct 2009

Abstract excerpt

The role of the 3'untranslated region (UTR) of the dengue virus (DENV) genome during viral translation remains to be elucidated. We assessed the contribution of well-defined RNA elements in the 3'UTR of DENV-2 to viral translation using a virus-induced reporting gene system and deoxyribozymes (DRzs) targeting the 3'UTR of the DENV-2 genome. Results show that mRNAs carrying a deletion of repeated conserved...

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Identifiers

PMID: 19861617
DOI: 10.4269/ajtmh.2009.08-0595

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