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Article

Evolution in health and medicine Sackler colloquium: The comparative genomics of viral emergence.

Proceedings of the National Academy of Sciences of the United States of America - 26 Jan 2010

Holmes Edward C

Abstract excerpt

RNA viruses are the main agents of emerging and re-emerging diseases. It is therefore important to reveal the evolutionary processes that underpin their ability to jump species boundaries and establish themselves in new hosts. Here, I discuss how comparative genomics can contribute to this endeavor. Arguably the most important evolutionary process in RNA virus evolution, abundant mutation, may even open up...

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Identifiers

PMID: 19858482
DOI: 10.1073/pnas.0906193106
PMCID: PMC2868293

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