Article
Array comparative genomic hybridization profiling analysis reveals deoxyribonucleic acid copy number variations associated with premature ovarian failure.
The Journal of clinical endocrinology and metabolism - 1 Nov 2009
Aboura Azzedine, Dupas Claire, Tachdjian Gérard, Portnoï Marie-France, Bourcigaux Nathalie, Dewailly Didier, Frydman René, Fauser Bart, Ronci-Chaix Nathalie, Donadille Bruno, Bouchard Philippe, Christin-Maitre Sophie
Abstract excerpt
INTRODUCTION: Premature ovarian failure (POF) is defined by amenorrhea of at least 4- to 6-month duration, occurring before 40 yr of age, with two FSH levels in the postmenopausal range. Its etiology remains unknown in more than 80% of cases. Standard karyotypes, having a resolution of 5-10 Mb, have identified critical chromosomal regions, mainly located on the long arm of the X chromosome. Array comparative...
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