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Article

Loss-of-function CYP2C9 variants improve therapeutic response to sulfonylureas in type 2 diabetes: a Go-DARTS study.

Clinical pharmacology and therapeutics - 1 Jan 2010

Zhou K, Donnelly L, Burch L, Tavendale R, Doney A S F, Leese G, Hattersley A T, McCarthy M I, Morris A D, Lang C C, Palmer C N A, Pearson E R

Abstract excerpt

Sulfonylureas are metabolized mainly by the cytochrome p450 2C9 (CYP2C9) enzyme. Two CYP2C9 variants--*2 (Arg144Cys) and *3 (Ile359Leu)--are associated with reduced enzyme activity and impaired substrate metabolism. We identified 1,073 incident users of sulfonylureas in Tayside, Scotland, and assessed the impact of the combined CYP2C9*2 and CYP2C9*3 genotypes on early and sustained sulfonylurea response. We found...

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Identifiers

PMID: 19794412
DOI: 10.1038/clpt.2009.176

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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