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Article

Two approaches to discovering and developing new drugs for Chagas disease

1 Jul 2009

Abstract excerpt

This review will focus on two general approaches carried out at the Sandler Center, University of California, San Francisco, to address the challenge of developing new drugs for the treatment of Chagas disease. The first approach is target-based drug discovery, and two specific targets, cytochrome P450 CYP51 and cruzain (aka cruzipain), are discussed. A 'proof of concept' molecule, the vinyl sulfone inhibitor...

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PMID: 19753483
DOI: 10.1590/s0074-02762009000900034

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