Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lower linkage disequilibrium at CNVs is due to both recurrent mutation and transposing duplications.

Molecular biology and evolution - 1 Jan 2010

Schrider Daniel R, Hahn Matthew W

Abstract excerpt

Copy number variants (CNVs) within humans can have both adaptive and deleterious effects. Because of their phenotypic significance, researchers have attempted to find single nucleotide polymorphisms (SNPs) in high linkage disequilibrium (LD) with CNVs to use in genomewide association studies. However, studies have found that CNVs are less likely to be in strong LD with flanking markers. We hypothesized that this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Mapping
Share to DNA Copy Number Variations
Share to Gene Duplication

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetics, Population

Share to Linkage Disequilibrium

Share to Models, Genetic

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 19745000
DOI: 10.1093/molbev/msp210
PMCID: PMC2877554

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lower linkage disequilibrium at CNVs is due to both recurrent mutation and transposing duplications.PMID 19745000Read ↗

Human copy number variants are enriched in regions of low mappability.Semantic proximity Read ↗

Human copy number variants are enriched in regions of low mappabilitySemantic proximity Read ↗

Insights into dispersed duplications and complex structural mutations from whole genome sequencing 706 familiesSemantic proximity Read ↗

Identification of recurrent regions of Copy-Number Variants across multiple individuals.Semantic proximity Read ↗

DNA sequence features underlying large-scale duplications and deletions in humanSemantic proximity Read ↗

Analysis of copy number variants and segmental duplications in the human genome: Evidence for a change in the process of formation in recent evolutionary history.Semantic proximity Read ↗

Population-genetic nature of copy number variations in the human genome.Semantic proximity Read ↗

Mutational and selective effects on copy-number variants in the human genome.Semantic proximity Read ↗

Origins and functional impact of copy number variation in the human genome.Semantic proximity Read ↗

Population analysis of large copy number variants and hotspots of human genetic disease.Semantic proximity Read ↗

Linkage disequilibrium and heritability of copy-number polymorphisms within duplicated regions of the human genome.Semantic proximity Read ↗

Novel origins of copy number variation in the dog genome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.