[Familial predisposition to chronic obstructive pulmonary disease].

Abstract excerpt

The role of cigarette smoking in development of chronic obstructive pulmonary disease (COPD) is well known, however only in about 20% of smokers clinical disease was diagnosed. It points to additional factors which influence the sensitivity to tobacco products. Familial clustering of COPD has been observed and genetic deficiency of alpha 1 antitrypsine with ZZ phenotype was proved to be a factor responsible for...

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