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Article

Mice deficient in the serine/threonine protein kinase VRK1 are infertile due to a progressive loss of spermatogonia.

Biology of reproduction - 1 Jan 2010

Wiebe Matthew S, Nichols R Jeremy, Molitor Tyler P, Lindgren Jill K, Traktman Paula

Abstract excerpt

The VRK1 protein kinase has been implicated as a pro-proliferative factor. Genetic analyses of mutant alleles of the Drosophila and Caenorhabditis elegans VRK1 homologs have revealed phenotypes ranging from embryonic lethality to mitotic and meiotic defects with resultant sterility. Herein, we describe the first genetic analysis of murine VRK1. Two lines of mice containing distinct gene-trap integrations into the...

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Source

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Identifiers

PMID: 19696012
DOI: 10.1095/biolreprod.109.079095
PMCID: PMC2802121

Genes

VRK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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