Article
Presence of activating KRAS mutations correlates significantly with expression of tumour suppressor genes DCN and TPM1 in colorectal cancer.
BMC cancer - 13 Aug 2009
Mlakar Vid, Berginc Gasper, Volavsek Metka, Stor Zdravko, Rems Miran, Glavac Damjan
Abstract excerpt
BACKGROUND: Despite identification of the major genes and pathways involved in the development of colorectal cancer (CRC), it has become obvious that several steps in these pathways might be bypassed by other as yet unknown genetic events that lead towards CRC. Therefore we wanted to improve our understanding of the genetic mechanisms of CRC development. METHODS: We used microarrays to identify novel genes...
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