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Article

Molecular analysis of aldolase B genes in hereditary fructose intolerance.

Lancet (London, England) - 10 Feb 1990

Cross N C, de Franchis R, Sebastio G, Dazzo C, Tolan D R, Gregori C, Odievre M, Vidailhet M, Romano V, Mascali G

Abstract excerpt

The molecular basis of hereditary fructose intolerance (HFI) was studied in 50 subjects (41 pedigrees, 82 apparently independent mutant alleles of aldolase B) by direct analysis of aldolase B genes amplified by means of the polymerase chain reaction. The mutation A149P (ala 149----pro) was found in 67% of alleles but was significantly more common in patients from northern than from southern Europe. Two other...

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PMID: 1967768
DOI: 10.1016/0140-6736(90)90603-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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