Article
Genetic polymorphisms and expression of minisatellite mutations in a 3-generation population around the Semipalatinsk nuclear explosion test-site, Kazakhstan.
International journal of hygiene and environmental health - 1 Nov 2009
Bolegenova N K, Bekmanov B O, Djansugurova L B, Bersimbaev R I, Salama S A, Au W W
Abstract excerpt
We have reported previously that a population near the Semipalatinsk nuclear explosion test site had significantly increased minisatellite mutations (MM), suggesting increased germ-line mutation rates from the exposure in 3 generations. We hypothesize that the MM can be used as a surrogate biomarker for functional genetic alterations, e.g. gene mutations and chromosome aberrations. Therefore, we have investigated...
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