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A low-cost, high-throughput, automated single nucleotide polymorphism assay for forensic human DNA applications.

Analytical biochemistry - 1 Dec 2009

Pomeroy Robert, Duncan George, Sunar-Reeder Bulbin, Ortenberg Elen, Ketchum Melba, Wasiluk Hannah, Reeder Dennis

Abstract excerpt

Single nucleotide polymorphism (SNP) analysis of human DNA for the purpose of identification has some promising attributes. The question of approach is critical to the eventual adoption of this technology. The use of a low-volume open array platform was tested with a small selected set of eight SNP primers that have a low F(ST) (the proportion of the total genetic variance contained in a subpopulation [S...

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PMID: 19646946
DOI: 10.1016/j.ab.2009.07.041

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