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Article

Role of ERCC1 promoter hypermethylation in drug resistance to cisplatin in human gliomas

22 Jul 2009

Abstract excerpt

Overexpression of ERCC1 mRNA is associated with drug resistance to cisplatin in human gliomas, but the role of the ERCC1 promoter in drug resistance has not been demonstrated. We have used sodium bisulfite sequencing to compare ERCC1 promoter methylation patterns in cisplatin-sensitive and cisplatin-resistant glioma cells. The levels of ERCC1 DNA methylation, mRNA and protein in 32 human glioma samples were...

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PMID: 19626585
DOI: 10.1002/ijc.24772

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