Article
Asymptomatic children with multiple endocrine neoplasia type 1 mutations may harbor nonfunctioning pancreatic neuroendocrine tumors.
The Journal of clinical endocrinology and metabolism - 1 Oct 2009
Newey Paul J, Jeyabalan Jeshmi, Walls Gerard V, Christie Paul T, Gleeson Fergus V, Gould Steve, Johnson Paul R V, Phillips Rachel R, Ryan Fiona J, Shine Brian, Bowl Michael R, Thakker Rajesh V
Abstract excerpt
CONTEXT: Multiple endocrine neoplasia type 1 (MEN1) is characterized by the occurrence of parathyroid, pituitary, and pancreatic tumors. MEN1, an autosomal dominant disorder, has a high degree of penetrance, such that more than 95% of patients develop clinical manifestations by the fifth decade, although this is lower at approximately 50% by age 20 yr. However, the lower penetrance in the younger group, which is...
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