Article
The ClinSeq Project: piloting large-scale genome sequencing for research in genomic medicine.
Genome research - 1 Sept 2009
Biesecker Leslie G, Mullikin James C, Facio Flavia M, Turner Clesson, Cherukuri Praveen F, Blakesley Robert W, Bouffard Gerard G, Chines Peter S, Cruz Pedro, Hansen Nancy F, Teer Jamie K, Maskeri Baishali, Young Alice C, Manolio Teri A, Wilson Alexander F, Finkel Toren, Hwang Paul, Arai Andrew, Remaley Alan T, Sachdev Vandana, Shamburek Robert, Cannon Richard O, Green Eric D
Abstract excerpt
ClinSeq is a pilot project to investigate the use of whole-genome sequencing as a tool for clinical research. By piloting the acquisition of large amounts of DNA sequence data from individual human subjects, we are fostering the development of hypothesis-generating approaches for performing research in genomic medicine, including the exploration of issues related to the genetic architecture of disease,...
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