Article
Genetic variation in the rhythmonome: ethnic variation and haplotype structure in candidate genes for arrhythmias.
Pharmacogenomics - 1 Jun 2009
Bush William S, Crawford Dana C, Alexander Charles, George Alfred L, Roden Dan M, Ritchie Marylyn D
Abstract excerpt
AIMS: The 'rhythmonome' is the term we have adopted to describe the set of genes that determine the normal coordinated electrical activity in the heart. Elements of this set include pore-forming ion channels, function-modifying proteins and intracellular calcium control elements. Rare mutations in many of these genes are known to cause unusual congenital monogenic arrhythmia syndromes, and single common variants...
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