Article
Fine mapping of the FecL locus influencing prolificacy in Lacaune sheep.
Animal genetics - 1 Dec 2009
Drouilhet L, Lecerf F, Bodin L, Fabre S, Mulsant P
Abstract excerpt
In the Lacaune sheep population, two major loci influencing ovulation rate are segregating: FecX and FecL. The FecX(L) mutation is a non-conservative substitution (p.Cys53Tyr) in BMP15 that prevents the processing of the protein. Using a statistical approach, FecL has been shown to be an autosomal major gene. A full genome scan localized the FecL locus on sheep chromosome 11. Fine mapping reduced the interval...
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