Article
Activated forms of VEGF-C and VEGF-D provide improved vascular function in skeletal muscle.
Circulation research - 5 Jun 2009
Anisimov Andrey, Alitalo Annamari, Korpisalo Petra, Soronen Jarkko, Kaijalainen Seppo, Leppänen Veli-Matti, Jeltsch Michael, Ylä-Herttuala Seppo, Alitalo Kari
Abstract excerpt
The therapeutic potential of vascular endothelial growth factor (VEGF)-C and VEGF-D in skeletal muscle has been of considerable interest as these factors have both angiogenic and lymphangiogenic activities. Previous studies have mainly used adenoviral gene delivery for short-term expression of VEGF-C and VEGF-D in pig, rabbit, and mouse skeletal muscles. Here we have used the activated mature forms of VEGF-C and...
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