Article
Paradoxical effect of Klebsiella pneumoniae OmpK36 porin deficiency.
Pathology - 1 Jan 2009
Jiang Xiuhong, Espedido Bjorn A, Partridge Sally R, Thomas Lee C, Wang Feng, Iredell Jonathan R
Abstract excerpt
AIM: To evaluate the effect of defined mutations in the major OmpK35 and OmpK36 porins in Klebsiella pneumoniae on the activity of two common plasmid-mediated AmpC enzymes. METHODS: Naturally occurring conjugative plasmids containing bla(DHA-1) and bla(CMY-2) were obtained from K. pneumoniae isolates in western Sydney. These were moved into K. pneumoniae ATCC13883 and isogenic porin knockouts Kp885 (DeltaompK35)...
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