Article
Antifungal drug resistance mechanisms.
Expert review of anti-infective therapy - 1 May 2009
Pemán Javier, Cantón Emilia, Espinel-Ingroff Ana
Abstract excerpt
Antifungal resistance is a prominent feature in the management of invasive mycoses, with important implications for morbidity and mortality. Microbiological resistance, the most common cause of refractory infection, is associated with a fungal pathogen for which an antifungal MIC is higher than average or within the range designated as the resistant breakpoint. Four major mechanisms of resistance to azoles have...
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